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Topictal (Topiramate)

Topictal is a very potent anticonvulsant that is structurally different from other AEDs. It is derived from D-fructose and initially was developed as an antidiabetic drug. In animal models, it was found to have potent antiepileptic effects. Topictal has multiple mechanisms of action. It exerts an inhibitory effect on sodium conductance, decreasing the duration of spontaneous bursts and the frequency of generated action potentials, enhances GABA by unknown mechanisms, inhibits the AMPA subtype glutamate receptor, and is a weak inhibitor of carbonic anhydrase. Topictal is absorbed rapidly after oral administration and has a bioavailability close to 100%. When it is administered at regular doses, food delays but does not affect the extent of absorption.

Other names for this medication:
Topiramate, Topamax, Epitomax, Letop, Neutop, Piramax, Talopam, Topamac, Topictal, Topigen, Topilex, Topimax, Topina, Topiramato, Topirol, Toplep,

Similar Products:
Metrolag, Benj, Lozar, Gantin, Viratop, Synermox, Taven, Deflamon, Sortiva, Ramimed, Tenox, Disulfiram, Atam, Tandam, Licoprima, Gabalept, Amoxy, Naklofen, Pres, Cefpodoxime, Zipant, Ampliron, Alfural, Resto, Advagraf,

Topictal is a medicine used to treat epilepsy. These are also called anti-epileptic medicines.

It can also be taken to prevent migraine.

This medicine is only available on prescription. It comes as tablets or capsules.

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Plasma warfarin concentration (W), measured by gas chromatography, and prothrombin time (PT), measured by the one-stage assay of Quick, were determined daily. (some comments on the use of FISH method for dose reconstruction for Techa riverside Residents). Size and function of the thyroid gland were evaluated by clinical aspects and with in vivo- and in vitro-methods for thyroid diagnostic. marneffei infection and PPE may be the signs of advanced HIV infection.

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Demonstrated with the example of the treatment of a compulsive neurotic patient Myelography at the above hospital revealed a complete block at the seventh thoracic level. The completed questionnaires were analysed with descriptive statistics. Furthermore, we showed that ordinal numerical judgement abilities predict arithmetic abilities after controlling for serial order WM abilities while the relationship between serial order WM and arithmetic abilities was mediated by numerical ordinal judgement performance. The renotropic growth stimulating factor is heat unstable and undialyzable by dialysis tubings with pore size up to 12,000 molecular weight.

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Comparative study of room-temperature phosphorescence of 1-bromonaphthalene induced by synergetic effect of nonionic surfactants and beta-cyclodextrin Maternal obesity is associated with increased frequencies of hypertension, preeclampsia, gestational diabetes mellitus, fetal macrosomia, congenital malformations, labor abnormalities (including prolonged second stage of labor, meconium-stained amniotic fluid, FHR abnormalities and shoulder dystocia), postdatism, and cesarean delivery. Particular methods for the purpose of separating substances by means of paper chromatography We searched for small molecules that inhibit polyglutamine-mediated aggregation by in vitro screening with a mutant myoglobin containing a 35 polyglutamine repeat. To describe the natural history of frailty transitions in a large cohort of community-dwelling older men and identify predictors associated with progression to or improvement from states of greater frailty.

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Supporting participants to achieve an appropriate intensity of practice of highly challenging balance activities appears to be critical to maximizing effectiveness. YB-1 and Puralpha are transcriptional repressors of fas and decreased basal transcription by 60-fold in reporter gene assays. IL-1 beta mRNA was released from polyribosomes by treating the cells with puromycin, suggesting that the ribosomes are not frozen at the elongation phase of protein synthesis. Twenty-one adolescents in group 1 and 25 of those in group 2 had a sexually transmitted infection. Results were edited by the technologist who scored them initially.

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No significant differences were found between the two utilizing periodic slit lamp examinations, measurements of intraocular pressure, corneal thickness or corneal endothelial cell density. Hepatitis C shares common routes of infection with hepatitis B (HBV) and the human immunodeficiency virus (HIV). The relationship of age and privilege status to reaction time indices of schizophrenic motivation.

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A 26-month-old boy with Stage III abdominal ganglioneuroblastoma had tachycardia and hypertension. The xanthine oxidase activity of mouse regenerating liver has been shown to be elevated during the period of rapid liver growth and proliferation.

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Ovarian sarcoma with pathologic features of clear cell sarcoma of the kidney. Sound localization after unilateral lesions of inferior colliculus in the ferret (Mustela putorius). The subsequent favorable clinical course and outcome with resolution of symptoms confirmed the diagnosis of radiation osteitis.

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CYP4F22 is highly expressed at the site and timing of onset of keratinization during skin development. Beijingxin3 was confirmed to be safe to grow in soil with Cd level up to 3.39 mg kg(-1), with Cd accumulation in its shoots well below the permitted level, and Qiuxiang was still poor in tolerating low Cd stress (1.31 mg kg(-1)). Histopathological examination of liver biopsies revealed more severe and frequent abnormalities in treated dogs compared to controls, but similar types of abnormalities were found in both groups. Bighorn sheep and livestock shared exposure to Pasteurellaceae, viral, and endoparasite agents. Efficient computing capability and robustness property prove that our model can correct the lung boundary reliably and reproducibly.

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Computational simulation and interpretation of the low-lying excited electronic states and electronic spectrum of thioanisole. Clones demonstrate a 26- to 52-fold increase in productivity compared to controls after dhfr/methotrexate-mediated gene amplification and clone selection. A pulmonary lesion with mediastinal adenopathies was detected in a 69-year-old, non-smoking female of Turkish origin during work-up for back pain. Use of 18F-FDG positron emission tomography following allogeneic transplantation to guide adoptive immunotherapy with donor lymphocyte infusions. Initial human experience of endoscopic ultrasound-guided photodynamic therapy with a novel photosensitizer and a flexible laser-light catheter.

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Psychotic symptoms occur more frequently in the general population than psychotic disorder and index risk for psychopathology. Radiation colitis typically emerges during radiotherapy of intra-abdominal malignancies. Effect of hypo- and hyperglycemic conditions on the development of chloral hydrate induced sleep Comparison to the TAMSD technique, shows that FIMA estimation is superior in many scenarios.

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Linkage between late onset, dominant spinocerebellar ataxia and HLA. Although the respondents believed their colleagues were very likely to behave in an ethical way in response to a situation that is susceptible to overtreatment, they still seemed to be concerned about the prevalence of unethical behaviors in this regard. Technique for continuous sampling of peritoneal fluid for prediction of intestinal gangrene. We observed that graft orientation made no difference in the histologic appearance or the thickness of the neocartilage formed.

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TEP should be a consensus document and supervised by the Pharmacy and Therapeutics Commission. DNA vaccines against cancer have to activate an inadequate or damaged immune system in order to attack residual cancer cells. Using the dynamic equilibrium affinity electrophoresis approach, we have shown that molecular components interacting with a low affinity are easily located on the virtual 2-D gels, and that binding constants and stoichiometry of the interactions can be assessed. Despite antibiotic chemotherapy and vitamins, the disease progressed. One of the two latter patients had isolated solitary median maxillary central incisor without other visible dentofacial anomalies, while the other had clinical features not part of the known holoprosencephaly spectrum.

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TEMPORARY REMOVAL: Peptides from frog skin with potential for development into agents for Type 2 diabetes therapy. The detection limit was ten melanoma cells per 10(7) peripheral blood lymphocytes.

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PET/CT correctly localized 8 foci in 4 patients to bone, indicating osteomyelitis. The highest levels of free amino acids were recorded for Contender variety and Swissblan one. This analysis describes the flow of key messages delivered through the Care Group model during this intervention. Analysis of gut microbial communities revealed that SPF SW mice carried abundant Bacteroides organisms when compared to SPF C57BL6/N mice, with B.

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It was concluded that parts of pi-mechanism curves probably reflect the responses of colour-opponent processes rather than those of single cone types. Correlation of Cardiac Markers and Biomarkers With Blood Pressure of Middle-Aged Marathon Runners.

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Polypeptides of interest were subsequently identified by liquid chromatography-linked tandem mass spectrometry. Different distributions of the data were allowed in 30 intervals of days in milk (DIM), covering the lactation from 5 to 305 days. The results highlight the importance of variables at micro- and exosystem levels as facilitating factors, and reinforce the ecological approach as being well suited for SE/health education in schools.

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Macrophage depletion should only be considered as therapeutic tool for discordant islet xenotransplantation. We found that population structure is not stable over time: we found population differentiation at the regional scale in the first year of sampling, but not in the second year.

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In adolescents and young adults, primary hyperparathyroidism (PHPT) is an uncommon diagnosis. The receptor expression and particle binding properties of MH-S are similar to AM in many, but not all, ways. In contrast, two distinct types of neurons, one medium-sized and the other small, were identified with the light microscope in Golgi-Cox and 1-micrometer Epon sections and with the electron microscope in ultrathin sections. At least two types of phycoerythrin (I and II) can be distinguished by electrophoresis, chromatography, and spectral characteristics. Restoration of latent inhibition by olanzapine but not haloperidol in entorhinal cortex-lesioned rats.

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Additionally, EGL repressed the levels of the claudin family members, which are major components of TJs that play a key role in the control and selectivity of paracellular transport. These data implicate serine/threonine phosphatases in v-Src-induced transformation.

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Thus, the decreased induction of hsp70 synthesis observed in the TT HeLa cells may be due to the immediate repression of activated cellular HSF, which probably results in the reduced induction of hsp70 mRNA. A mutant of eukaryotic protein synthesis initiation factor eIF4E(K119A) has an increased binding affinity for both m7G cap analogues and eIF4G peptides. The gender-specific time use behaviors offer intervention design possibilities.

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Drug-coated balloon (DCB) therapy offers a viable alternative to DESs for the management of small vessel CAD. Rats with neonatal ventral hippocampal (nVH) lesions show postpubertal hypersensitivity to dopamine agonists, which may be reversed by neuroleptic treatment.

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Characterization and ultrafiltration of semiconductor indium phosphide (InP) wastewater for recycling. Human health consequences of environmentally-modulated gene expression: potential roles of ELF-EMF induced epigenetic versus mutagenic mechanisms of disease. Interestingly, loss-of-function mutants of OSH1 lose the SAM just after germination but can be rescued to grow until reproductive development when they are regenerated from callus.

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Similarly, a transient decrease was observed for plasma levels of C peptide after unopposed 17beta-estradiol. Demographic and clinical characteristics of the patients (Mini Mental State Examination, MMSE), Koedam score on cranial magnetic resonance imaging, and blood parameters (TSH, FT4, and nitric oxide - NOx) were assessed. Experimental researches on the action of microwaves (radar) on the cat heart

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Inter-data center interconnect with IP over elastic optical network (EON) is a promising scenario to meet the high burstiness and high-bandwidth requirements of data center services. Basilar artery remodelling in the genetically hypertensive rat: effects of nitric oxide synthase inhibition and treatment with valsartan and enalapril. Identifying the mechanisms through which cell defense properties act will help clarify the process responsible for beta-cell regeneration in type I diabetes patients.

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These improvements in the local wound environment seem to accelerate wound healing compared with traditional methods. The assumptions necessary to perform ECG-gated cardiac studies are seemingly not valid for patients in atrial fibrillation (AF). Psychiatric nursing implications include the importance of assessing early childhood adversity during psychosocial assessments. Furthermore, transesophageal echocardiography revealed a left-to-right shunt flow into the coronary sinus through the defect.

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The understanding of the phenomenon allows us to statistically align both clusters and resulting superstructures on patterned substrates, opening the way to rapid screening in molecular electronics. Among the broad array of genes that have been evaluated for tumor therapy, those encoding prodrug activation enzymes are especially appealing as they directly complement ongoing clinical chemotherapeutic regimes. Paradoxical tuberculosis (TB)-associated Immune Reconstitution Inflammatory Syndrome (IRIS) is a common complication of combination antiretroviral treatment (cART) initiation in adults residing in resource-limited regions. Four electrocardiograph leads (I, aVR, V1, V5) recorded in eight healthy people relaxing in a semirecumbent position.

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The purpose of comprehensive ophthalmic screening in SLE patients is twofold. At 14 and 16 days of gestation, immature and transitional forms of DCs dominated. Our model differs from others in that it is based on a scaffold-less, self-aggregating culture model that produces a cartilage tissue analog that has been shown to share many similarities with the natural cartilage phenotype. We constructed vectors encoding a constitutively active form of human caspase 8 (CC8), and demonstrated the efficient killing of a variety of cell types in transfection and lentivirus-transduction assays. Clinical significance of hypointensity in the motor cortex on T2-weighted images.

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There are few population-based data regarding the effectiveness of inferior vena cava filter use in the prevention of symptomatic pulmonary embolism. Intraoperative interstitial implantation of iridium 192 in the breast. Acidic steroids were separated from a 4-day pool of feces and subjected, after fractionation, to gas liquid chromatography and mass spectrometry. Peptides derived from tryptic hydrolysate of Bacillus subtilis culture suppress fungal spoilage of table grapes.

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Effects of egg yolk inclusion, milk replacer feeding rate, and low-starch (pelleted) or high-starch (texturized) starter on Holstein calf performance through 4 months of age. Interneuronal and nerve-tissue connections in human sympathetic ganglia This report describes the time course of CYP2D6 antibodies and the appearance of anti-SMA (without anti-actin, cytokeratin and vimentin reactivity) associated with acute rejection during a 2-year follow-up, in a patient who underwent transplantation at end-stage type 2 autoimmune hepatitis. However, it has been possible to synthesize chemically stable single photon glucose analogues interacting with glut(s), glucose transporters.

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In general, hyponatremia associated with volume depletion is treated with saline, while fluid restriction is the primary therapy in patients with normal or increased extracellular fluid volume. We surveyed 582 members of the American Society of Dermatopathology via a web-based questionnaire to evaluate the practice of reporting surgical margins in melanocytic lesions. Various combinations of in situ and invasive carcinomas were found.

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Endothelial cell culture as a model for the study of wound healing Placental angiogenesis in sheep models of compromised pregnancy. Overexpression and purification of recombinant eel calcitonin and its phylogenetic analysis. The share of patient care in systems as opposed to independent hospitals rose from 39 to 57 percent.

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The question surrounding the colonization of Polynesia has remained controversial. Comparative roentgenological examinations of the small intestines in healthy infants with different foods

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Female genital tuberculosis and sterility: outline of the problem A single, oral administration of NAC (200 or 1000 mg/kg body wt) significantly suppressed the enhanced TNF production in the diabetic rats compared with that in untreated rats in a dose-dependent manner. Thus, the implantation of BMP with the BMP-responding cells could restore large bone defects even in elderly patients. We have developed a software application designed specifically for this task. Catalytic transformation rates for gaseous CO2 hydration were calculated for each type of immobilization.

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Pharmacokinetics and cardiovascular effects of YM-21095, a novel renin inhibitor, in dogs and monkeys. Using intention to treat analysis (multiple imputation), the patients showed substantial improvements in eating attitudes, bulimic behaviors, and depression.

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tuberculosis iniA gene (Rv 0342) participates in the development of tolerance to both INH and EMB. The loss of wall integrity suggests that during the process of mounting the xenograft on the flexible stent, the aortic walls of the bioprosthesis may have been thinned beyond a critical point of maintenance of wall strength. In group 2, abnormalities were observed in the S group only, and the kidneys of rabbits in group 3 suffered oxidative damage and mitochondrial injuries with increased NGAL, decreased Mn-SOD, GR and CAT,increased MDA and H2O2, lower levels of MMP, mitochondrial vacuolization and an increased apoptotic index. We report three cases of double aortic arch diagnosed by a 16-row MSCT, and discuss the possible advantages of this diagnostic tool.

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Microarray analyses have given important new information about atherogenesis. We examined the ability of multiple pathways to explain socioeconomic differentials in all-cause mortality in South Korea. Muscular-skeletal disorders of the upper limbs resulting from work involving repetition strain (RSI) are now the most frequent work-related diseases in early or late industrialized countries.

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Blood samples were taken from both groups for determination of superoxide dismutase, glutathione peroxidase, novo methacin gout cure and their cofactors, which are selenium, copper, and zinc levels. Comprehensive comparisons were conducted to assess LANN-SVD against other state-of-the-art algorithms.

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Serial measurements in 23 patients with elevated postoperative CT levels showed exponential increases in basal CT levels in 19 patients (p less than 0.05 in nine patients, 0.05 less than p less than 0.1 in pegasys package insert 2012 olympics four patients) and slight decreases in four (p less than 0.05 in one patient). Increased levels of apoptosis in the prefusion neural folds underlie the craniofacial disorder, Treacher Collins syndrome.

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